2023 / 01

Next Paper
DOI: 10.47183/mes.2023.001

METHOD

Experimental animal model for treatment of absolute uterine factor infertility

Polstyanoy AM1,2, Polstyanaya OYu1,2, Rendashkin IV1, Yakimenko ON1,2, Tutsenko KO1,2, Sadovsky MG1,2,3, Chernova AA1,2
About authors

1 Federal Siberian Research Clinical Center of the Federal Medical Biological Agency, Krasnoyarsk, Russia

2 Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia

3 Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia

Correspondence should be addressed: Anna A. Chernova
Krasnodarskaya, 40/4, Krasnoyarsk, 660133, Russia; ur.xednay@ksrk-avonrehc

About paper

Funding: the study was conducted as part of the State Assignment of FMBA of Russia.

Author contribution: Polstyanoy AM — developing the surgical protocol for uterus transplantation; Polstyanaya OYu — experimental planning; Rendashkin IV — literature analysis; Yakimenko ON — ethical aspects of study planning; Tutsenko KO — statistical analysis; Sadovsky MG — comparative analysis of experimental data; Chernova AA — management, study planning.

Compliance with the ethical standards: the study was conducted in accordance with the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes (Strasbourg, 1986) and the Rules for Handling Experimental Animals (order № 755 of 12.08.1977 of the Ministry of Health of the USSR).

Received: 2022-09-22 Accepted: 2022-12-11 Published online: 2023-01-20
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  1. Brännström M, et al. Livebirth after uterus transplantation. The Lancet. 2015; 385 (9968): 607–16.
  2. Brännström M, et al. Uterus transplantation: animal research and human possibilities. Fertility and Sterility. 2012; 97 (6): 1269–76.
  3. Brinsden P. Gestational surrogacy. Human Reproduction Update. 2003; 9 (5): 483–91.
  4. Chan Y, et al. Reproductive outcomes in women with congenital uterine anomalies: a systematic review. Ultrasound in Obstetrics & Gynecology. 2011; 38 (4): 371–82.
  5. El-Akouri R. Successful uterine transplantation in the mouse: pregnancy and post–natal development of offspring. Human Reproduction. 2003; 18 (10): 2018–23.
  6. McCulloch P, et al. No surgical innovation without evaluation: the IDEAL recommendations. The Lancet. 2009; 374 (9695): 1105–12.
  7. Adachi M, et al. Evaluation of allowable time and histopathological changes in warm ischemia of the uterus in cynomolgus monkey as a model for uterus transplantation. Acta Obstetricia et Gynecologica Scandinavica. 2016; 95 (9): 991–8.
  8. Akhi S, et al. Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus. Fertility and Sterility. 2013; 99 (3): 862–70.
  9. Díaz-García C, et al. The effect of warm ischemia at uterus transplantation in a rat model. Acta Obstetricia et Gynecologica Scandinavica. 2012; 92 (2): 152–9.
  10. Kisu I, et al. A new surgical technique of uterine auto– transplantation in cynomolgus monkey: preliminary report about two cases. Archives of Gynecology and Obstetrics. 2011; 285 (1): 129–37.
  11. Enskog A, et al. Uterus transplantation in the baboon: methodology and long–term function after auto–transplantation. Human Reproduction. 2010; 25 (8): 1980–7.
  12. El-Akouri R. Pregnancy in transplanted mouse uterus after long– term cold ischaemic preservation. Human Reproduction. 2003; 18 (10): 2024–30.
  13. Groth K, et al. Effects of immunosuppression by cyclosporine A on allogenic uterine transplant in the rat. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2012; 163 (1): 97–103.
  14. Tricard J, et al. Uterus tolerance to extended cold ischemic storage after auto–transplantation in ewes. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2017; 214: 162–7.
  15. Wranning C, et al. Uterus transplantation in the rat: Model development, surgical learning and morphological evaluation of healing. Acta Obstetricia et Gynecologica Scandinavica. 2008; 87 (11): 1239–47.
  16. Avison D, et al. Heterotopic Uterus Transplantation in a Swine Model. Transplantation. 2009; 88 (4): 465–9.
  17. Gauthier T, et al. Uterine allotransplantation in ewes using an aortocava patch. Human Reproduction. 2011; 26 (11): 3028–36.
  18. Gonzalez–Pinto I, et al. Uterus Transplantation Model in Sheep With Heterotopic Whole Graft and Aorta and Cava Anastomoses. Transplantation Proceedings. 2013; 45 (5): 1802–4.
  19. Gauthier T, et al. Uterus retrieval process from brain dead donors. Fertility and Sterility. 2014; 102 (2): 476–82.
  20. Johannesson L, et al. Vascular Pedicle Lengths After Hysterectomy. Obstetrics & Gynecology. 2012; 119 (6): 1219–25.
  21. Fronek J, et al. Human Uterus Transplantation from Living and Deceased Donors: The Interim Results of the First 10 Cases of the Czech Trial. Journal of Clinical Medicine. 2021; 10 (4): 586.