Effects of mild hypothermia on the cerebral microvascular tone

Melnikova NN
About authors

Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia

Correspondence should be addressed: Nadezhda N. Melnikova
nab. Makarova, 6, Saint Petersburg, 199034; ur.liam@nnlem

About paper

Funding: the study was supported by the State Programme 47 GP “Scientific and Technological Development of the Russian Federation” (2019–2030), project 0134-2019-003.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Commission for Care and Use of Laboratory Animals, Pavlov Institute of Physiology RAS (protocol № 05/10 of 10 May 2021) and conducted in accordance with the principles of the Declaration of Helsinki (2013).

Received: 2023-06-30 Accepted: 2023-08-07 Published online: 2023-08-20
Fig. 1. Experimental design
Fig. 2. Average blood pressure, heart rate and respiratory rate in rats during the experiment
Fig. 3. Changes in the diameter of pial arteries at different stages of the experiment
Fig. 4. Dynamic changes in the diameter of the rats’ pial arteries relative to baseline in different experimental groups
Table. Parameters of the rats’ functional state before the beginning of monitoring
Note: * — р ˂ 0.05, * * — р ˂ 0.01, * * * — р ˂ 0.001 when comparing to normal; † — р ˂ 0.05, †† — р — 0.01, ††† — р ˂ 0.001 when comparing baseline values with the values recorded during blood collection