ORIGINAL RESEARCH

Effects of mild hypothermia on the cerebral microvascular tone

Melnikova NN
About authors

Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg, Russia

Correspondence should be addressed: Nadezhda N. Melnikova
nab. Makarova, 6, Saint Petersburg, 199034; ur.liam@nnlem

About paper

Funding: the study was supported by the State Programme 47 GP “Scientific and Technological Development of the Russian Federation” (2019–2030), project 0134-2019-003.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Commission for Care and Use of Laboratory Animals, Pavlov Institute of Physiology RAS (protocol № 05/10 of 10 May 2021) and conducted in accordance with the principles of the Declaration of Helsinki (2013).

Received: 2023-06-30 Accepted: 2023-08-07 Published online: 2023-08-20
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  1. Perlman R, Callum J, Laflamme C, Tien H, Nascimento B, Beckett A, Alam A. A recommended early goal-directed management guideline for the prevention of hypothermia-related transfusion, morbidity, and mortality in severely injured trauma patients. Crit Care. 2016; 20 (1): 107. PubMed PMID: 27095272.
  2. Poh PY, Gagnon D, Romero SA, Convertino VA, Adams-Huet B, Crandall CG. Hemodynamic stability to surface warming and cooling during sustained and continuous simulated hemorrhage in humans. Shock. 2016; 46 (3 Suppl 1): 42–9. PubMed PMID: 27224744.
  3. van Veelen MJ, Brodmann Maeder M. Hypothermia in trauma. Int J Environ Res Public Health. 2021; 18 (16): 8719. PubMed PMID: 34444466.
  4. Rösli D, Schnüriger B, Candinas D, Haltmeier T. The impact of accidental hypothermia on mortality in trauma patients overall and patients with traumatic brain injury specifically: a systematic review and meta-analysis. World J Surg. 2020; 44 (12): 4106–17. PubMed PMID: 32860141.
  5. Rauch S, Miller C, Bräuer A, Wallner B, Bock M, Paal P. Perioperative Hypothermia-A Narrative Review. Int J Environ Res Public Health. 2021; 18 (16): 8749. PubMed PMID: 34444504.
  6. Grigorev EV, Lebedinskij KM, Shhegolev AV, Bobovnik SV, Bulanov AYu, Zabolotskix IB, i dr. Reanimaciya i intensivnaya terapiya pri ostroj massivnoj krovopotere u vzroslyx pacientov. Anesteziologiya i reanimatologiya. 2020; (1): 5–24. Russian.
  7. Bonanno FG. Management of hemorrhagic shock: physiology approach, timing and strategies. J Clin Med. 2023; 12 (1): 260. PubMed PMID: 36615060.
  8. Takasu A, Carrillo P, Stezoski SW, Safar P, Tisherman SA. Mild or moderate hypothermia but not increased oxygen breathing prolongs survival during lethal uncontrolled hemorrhagic shock in rats, with monitoring of visceral dysoxia. Crit Care Med. 1999; 27 (8): 1557–64. PubMed PMID: 10470764.
  9. Wu X, Stezoski J, Safar P, Nozari A, Tisherman SA. After spontaneous hypothermia during hemorrhagic shock, continuing mild hypothermia (34 degrees C) improves early but not late survival in rats. J Trauma. 2003; 55 (2): 308–16. PubMed PMID: 12913642.
  10. Hachimi-Idrissi S, Yang X, Nguyen DN, Huyghens L. Combination of therapeutic mild hypothermia and delayed fluid resuscitation improved survival after uncontrolled haemorrhagic shock in mechanically ventilated rats. Resuscitation. 2004: 62 (3): 303–10. PubMed PMID: 15325450.
  11. Wu X, Kochanek PM, Cochran K, Nozari A, Henchir J, Stezoski SW, et al. Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs. J Trauma. 2005; 59 (2): 291–301. PubMed PMID: 16294067.
  12. Alam HB, Rhee P, Honma K, Chen H, Ayuste EC, Lin T et al. Does the rate of rewarming from profound hypothermic arrest influence the outcome in a swine model of lethal hemorrhage? J Trauma. 2006; 60 (1): 134–46. PubMed PMID: 16456447.
  13. Jiang SY, Zhao YY, Zhao XG. Potential role of therapeutic hypothermia in the salvage of traumatic hemorrhagic shock. Crit Care. 2013; 17 (3): 318. PubMed PMID: 23714428.
  14. Hong JM, Choi ES, Park SY. Selective brain cooling: a new horizon of neuroprotection. Front Neurol. 2022; 20; 13: 873165. PubMed PMID: 35795804.
  15. Childs EW, Udobi KF, Hunter FA. Hypothermia reduces microvascular permeability and reactive oxygen species expression after hemorrhagic shock. J Trauma. 2005; 58 (2): 271–7. PubMed PMID: 15706187.
  16. Li T, Lin X, Zhu Y, Li L, Liu L. Short-term, mild hypothermia can increase the beneficial effect of permissive hypotension on uncontrolled hemorrhagic shock in rats. Anesthesiology. 2012; 116 (6): 1288–98. PubMed PMID: 22546964.
  17. He X, Su F, Taccone FS, Maciel LK, Vincent JL. Cardiovascular and microvascular responses to mild hypothermia in an ovine model. Resuscitation. 2012; 83 (6): 760–6. PubMed PMID: 22155698.
  18. Chun-Lin H, Jie W, Xiao-Xing L, Xing L, Yu-Jie L, Hong Z, et al. Effects of therapeutic hypothermia on coagulopathy and microcirculation after cardiopulmonary resuscitation in rabbits. Am J Emerg Med. 2011; 29 (9): 1103–10. PubMed PMID: 20951524.
  19. Gong P, Zhao S, Wang J, Yang Z, Qian J, Wu X, et al. Mild hypothermia preserves cerebral cortex microcirculation after resuscitation in a rat model of cardiac arrest. Resuscitation. 2015; 97: 109–14. PubMed PMID: 26485658.
  20. Wu J, Yuan W, Li J, Zhao Y, Li J, Li Z. Effects of mild hypothermia on cerebral large and small microvessels blood flow in a porcine model of cardiac arrest. Neurocrit Care. 2017; 27 (2): 297–303. PubMed PMID: 28405859.
  21. Donadello K, Su F, Annoni F, Scolletta S, He X, Peluso L, et al. The effects of temperature management on brain microcirculation, oxygenation and metabolism. Brain Sci. 2022; 12 (10): 1422. PubMed PMID: 36291355.
  22. Caminos Eguillor JF, Ferrara G, Kanoore Edul VS, Buscetti MG, Canales HS, Lattanzio B, et al. Effects of systemic hypothermia on microcirculation in conditions of hemodynamic stability and in hemorrhagic shock. Shock. 2021; 55 (5): 686–92. PubMed PMID: 32694390.
  23. Melnikova NN. Vozdejstvie sistemnoj gipotermii na reakcii pial'nyx arterij pri ostroj massivnoj krovopotere u narkotizirovannyx krys linii Wistar. Zhurnal ehvolyucionnoj bioximii i fiziologii. 2022; 58 (5): 382–92. Russian.
  24. Vasilev AG, Xajcev NV, Balashov AL, Balashov LD, Kravcova AA., Trashkov AP, i dr. O patogeneze sindroma ostroj krovopoteri. Pediatr. 2019; 10 (3): 93–100. Russian.
  25. Markina LD, Shiryaeva EE, Markin VV. Morfofunkcional'nye osobennosti pial'nyx arterij zon smezhnogo krovosnabzheniya golovnogo mozga v usloviyax ostroj cirkulyatornoj gipoksii. Tixookeanskij medicinskij zhurnal. 2015; (1): 40–2. Russian.
  26. Lycheva NA, Sedov AV, Makushkina DA, Shaxmatov II, Vdovin VM. Neprednamerennaya gipotermiya kak faktor narusheniya raboty mikrocirkulyatornogo rusla. Kazanskij medicinskij zhurnal. 2019; 100 (2): 252–6. Russian.
  27. Yu H, Wang L, Zhang H, Wei W, Chen Y, Tang W. Effect of mild hypothermia on cerebral microcirculation in a murine cardiopulmonary resuscitation model. Microcirculation. 2019; 26 (6): e12537. PubMed PMID: 30801897.
  28. Kurisu K, Kim JY, You J, Yenari MA. Therapeutic hypothermia and neuroprotection in acute neurological disease. Curr Med Chem. 2019; 26 (29): 5430–55. PubMed PMID: 31057103.