ISSN Print 2713-2757
ISSN Online 2713-2765
Extreme Medicine
SCIENTIFIC AND PRACTICAL REVIEWED JOURNAL OF FMBA OF RUSSIA
ORIGINAL RESEARCH
Estimation of mutagenic potential of the valproic acid derivative containing a tertiary amino group
About authors
Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency, Saint-Petersburg, Russia
Correspondence should be addressed: Ekaterina A. Zolotoverkhaja
Bekhtereva, 1, Saint-Petersburg, 192019, Russia; ur.xednay@ajahkrevotoloz.e
About paper
Funding: the study was performed as part of the State Assignment “Assessment of Effiacy and Safety of the Valproic Acid Amino Ester Substance as an Agent for Drug Treatment of the Toxin-Induced Seizures”, R&D project № 121041500281-1.
Author contribution: Zolotoverkhaja EA — study planning, in silico analysis, statistical analysis and data interpretation, manuscript writing; Kubarskaya LG — in vitro experiments, data acquisition and analysis; Bespalov AYa — synthesis of the test compound, data interpretation, manuscript editing; Melekhova AS — manuscript editing, preparing supportive documents for publishing.
Compliance with ethical standards: the study was performed in silico and in vitro, no approval by the Ethics Committee was required.
Received: 2023-06-20
Accepted: 2023-08-23
Published online: 2023-09-15
|
Table 1. Results of testing the valproic acid amino ester containing a tertiary amino group using the Ames assay involving no activation by microsomal fraction (M ± SD)
Note: # — decrease in the level of spontaneous reversions (B-value ≤ 0.01)
Table 2. Results of testing the valproic acid amino ester containing a tertiary amino group using the Ames assay involving activation by S9 microsomal fraction (M ± SD)
Note: # — decrease in the level of spontaneous reversions (B-value ≤ 0.01)
