ORIGINAL RESEARCH
Local treatment of a contaminated skin wound using an original drug combination and magnetic therapy in an experiment
Kursk State Medical University, Kursk, Russia
Correspondence should be addressed: Alexey G. Terekhov
Karla Marxa, 3, Kursk, 305041, Russia; ur.xednay@6464retxela
Author contribution: Terekhov AG — study concept and design, analysis of the resulting data, editing; Pankrusheva TA — design of the drug combination, data collection; Chekmareva MS — design of the drug combination, data collection; Turenko EN — collection of material, statistical data processing, analysis of the resulting data, article preparation; Artyushkova EB — collection of material, analysis of the resulting data; Mishina ES — collection of material, statistical data processing, analysis of the resulting data; Grigoryan AYu — analysis of the resulting data, article preparation, editing; Myatechkin AA — analysis of the resulting data, article preparation, editing.
Compliance with the ethical standards: the study was approved by the Ethics Committee of the Kursk State Medical University (Minutes #7 of November 30, 2020). The series of animal experiments, the conditions of their detention met the requirements of the Strasbourg Convention for the Protection of Animal Rights (France, 1986) and GOST 33044-2014 Principles of good laboratory practice.
- Markov SN, Spiridonov AA, Slepov AV. The possibility of using autologous adipose tissue for the stage shin wound closing. Wounds and wound infections. The Prof. BM Kostyuchenok Journal. 2021; 8 (3): 46–51. Russian.
- Kulikovich JK, LyzikovAA, Kaplan ML, Kovalenko AA, Usiankova VV. Long-term results of profundoplasty in patients with atherosclerotic lesions of the arteries of the lower extremities, depending on the state of the distal bed. Health and Ecology Issues. 2023; 20 (3): 46–52. Russian.
- Mansur HJ, Gatea FK. Effects of Topical Pentoxifylline on Induced Thermal Burn in Mice. International Journal of Pharmaceutical Quality Assurance. 2021; 12 (3): 299–305. DOI: 10.25258/ijpqa.12.3.26.
- Korolev DV, Shumatov VB, Plekhova NG. Local treatment of infected wounds depending on the phase of the wound process. Health & education millennium. 2023; 25 (7): 69–75. Russian.
- Shurshina AS, Kulish EI. Study of the diffusion process in films sodium salt of carboxymethyl cellulose — drug. Izvestiya of Saratov University. Chemistry. Biology. Ecology. 2021; 21 (4): 382–90. Russian.
- Lipatov VA, Kudryavtseva TN, Severinov DA. Application of cellulose derivatives in experimental surgery of parenchymal organs. Science of the young (Eruditio Juvenium). 2020; 8 (2): 269–83. DOI: 10.23888/hmj202082269-283. Russian.
- Proksch E, Berardesca E, Misery L, Engblom J, Bouwstra J. Dry Skin Management: Practical Approach in Light of Latest Research on Skin Structure and Function. J Dermatolog Treat. 2020; 31 (7): 716–22. DOI: 10.1080/09546634.2019.1607024.
- Jean–Yves Maillard. Impact of benzalkonium chloride, benzethonium chloride and chloroxylenol on bacterial antimicrobial resistance. Journal of Applied Microbiology. 2022; 133 (6): 3322–46.
- Dion MW, Hussey DH, Osborne JW. The effect of pentoxifylline on early and late radiation injury following fractionated irradiation in C3H mice. Int J Radiat Oncol Biol Phys. 1989; 17 (1): 101–7. DOI: 10.1016/0360-3016(89)90376-3. PMID: 2745184.
- Chupin AV, Pizova NV, Korshunov DA. Pentoxifylline in vascular pathology. RMJ. 2023; 3: 15–20. Russian.
- Bogatikov AA, Dobretsov KG, Melikhova MV, Rozhko MA, Lapina NV, Stolyar SV, et al. A new method for treating burn wounds using targeted delivery of medicinal substances by magnetic nanocarrier (experimental part). J. Sib. Fed. Univ. Biol. 2022; 15 (3): 422–36. Russian.
- Shanmugaraj K, Keerthanaa B. Influence of Autologous Platelet Concentrates on the Dynamics of Regenerative Processes in Treatment of Trophic Ulcers of Lower Extremities. Indian Journal of Public Health. 2019; 10 (11): 1851.
- Vasilev PV, Margaryants NB, Erofeev NP. Laser doppler flowmetry in the microlymphodynamics study. Sovremennye tehnologii v medicine. 2019; 11 (2): 92–7. Russian.
- Aghajani A, Kazemi T, Enayatifard R, Amiri FT, Narenji M. Investigating the skin penetration and wound healing properties of niosomal pentoxifylline cream. Eur J Pharm Sci. 2020; 151: 105434.
- Moreira VM, et al. Pentoxifylline/Chitosan Films on Wound Healing: In Vitro/In Vivo Evaluation. Pharmaceutics. 2023; 15 (4): 1122.
- Grigoryan AYu, Bezhin AI, Pankrusheva TA, Zhilyaeva LV, Mishina ES. Selection of the optimal basis for combination with benzalkonium chloride for the treatment of purulent wounds (experimental study). Journal of New Medical Technologies. 2021; 28 (2): 35–9. Russian.
- Shutov YuM, Shumkov OA, Veryatin YaA. Evaluation of the stimulating effect of platelet-enriched autoplasma and optimization of the resorption function of the lymphatic system on the healing of a trophic ulcer of venous etiology. Medicine. Sociology. Philosophy. Applied research. 2023; 1: 15–23. Russian.
- Bezhin AI, Lipatov VA, Fronchek EV, et al. Application chitosancollagen complex nano-particles of silver and chymotrypsin in the treatment of purulent necrotic wounds. Journal of New Medical Technologies. 2019; 26 (3): 23–8. DOI: 10.21626/vestnik/2019-2/01. Russian.
- Amareswari VH, Padma K, Dharmarajan P, Shivakumar S, Dhilip KS. Evaluation of Efficacy of Pulsed Electromagnetic Field Therapy as an Adjuvant Therapy in Healing of Diabetic Foot Ulcers. International Journal of Physiology. 2020; 8 (2): 6–12. DOI: 10.37506/ijop.v8i2.1234.
- Dixit S, Ahmad I, Gular K, Eid RA, Reddy RS, Ribeiro IL, et al. Efficacy of single versus multiple exposure by electromagnetic modalities on gram-negative and positive bacterial strains in an in-vitro model. Saudi J Biol Sci. 2021; 28 (3): 1678–86. DOI: 10.1016/j.sjbs.2020.12.004.