2023 / 04

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DOI: 10.47183/mes.2023.065

ORIGINAL RESEARCH

Local treatment of a contaminated skin wound using an original drug combination and magnetic therapy in an experiment

Terekhov AG, Pankrusheva TA, Chekmareva MS, Turenko EN, Artyushkova EB, Mishina ES, Grigoryan AYu, Myatechkin AA
About authors

Kursk State Medical University, Kursk, Russia

Correspondence should be addressed: Alexey G. Terekhov
Karla Marxa, 3, Kursk, 305041, Russia; ur.xednay@6464retxela

About paper

Author contribution: Terekhov AG — study concept and design, analysis of the resulting data, editing; Pankrusheva TA — design of the drug combination, data collection; Chekmareva MS — design of the drug combination, data collection; Turenko EN — collection of material, statistical data processing, analysis of the resulting data, article preparation; Artyushkova EB — collection of material, analysis of the resulting data; Mishina ES — collection of material, statistical data processing, analysis of the resulting data; Grigoryan AYu — analysis of the resulting data, article preparation, editing; Myatechkin AA — analysis of the resulting data, article preparation, editing.

Compliance with the ethical standards: the study was approved by the Ethics Committee of the Kursk State Medical University (Minutes #7 of November 30, 2020). The series of animal experiments, the conditions of their detention met the requirements of the Strasbourg Convention for the Protection of Animal Rights (France, 1986) and GOST 33044-2014 Principles of good laboratory practice.

Received: 2023-11-09 Accepted: 2023-12-19 Published online: 2023-12-31
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Fig. 1. Wound area reduction percentage (%), Me (25; 75). * — p < 0.05 in comparison of group 1 (control) and other groups; # — p < 0.05 in comparison of group 2 and group 3.
Fig. 2. Laser Doppler flowmetry dynamics (p.u.), Me (25; 75). * — p < 0.05 in comparison of group 1 (control) and other groups; # — p < 0.05 in comparison of group 2 and group 3
Fig. 3. Local wound temperature dynamics (°C), Me (25; 75); * — p < 0.05 in comparison of group 1 (control) and other groups; # — p < 0.05 in comparison of group 2 and group 3
Table 1. Dynamics of wound healing in the treated experimental animals, Me (25; 75)
Note: * — p < 0.05 in comparison of group 1 (control) and other groups; * * — p < 0.05 in comparison of group 2 and group 3.
Table 2. Wound pH changes, Me (25; 75)
Note: * — p < 0.05 in comparison of group 1 (control) and other groups; # — p < 0.05 in comparison of group 2 and group 3.