ORIGINAL RESEARCH

Effect of sodium bicarbonate or hydrochloric acid intragastric administration on gut-derived endotoxemia in rats receiving cyclophosphamide myeloablative conditioning

About authors

1 Golikov Research Clinical Center of Toxicology of the Federal Medical and Biological Agency, Saint-Petersburg, Russia

2 State Scientific Research Test Institute of the Military Medicine of Defense Ministry of the Russian Federation, Saint-Petersburg, Russia

Correspondence should be addressed: Tatiana B. Pechurina
Lesoparkovaya, 4, Saint-Petersburg, 195043, Russia; ur.tsil@97tat

About paper

Author contribution: Vakunenkova OA — experimental part of the study; Zolotoverkhaya EA — blood biochemistry testing; Pechurina TB — tissue biochemistry testing; Schäfer TV — experimental part of the study, data processing and visualization, developing the experimental model; Ivnitsky JuJu — research design, developing the experimental model, data interpretation and discussion. All authors contributed to discussion, manuscript writing and editing.

Compliance with ethical standards: the study was compliant with the principles of bioethics adopted by the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes.

Received: 2024-05-01 Accepted: 2024-06-26 Published online: 2024-06-30
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  1. Vakunenkova OA, Ivnitsky JJ, Gaykova ON, Kozlov AA, Schäfer TV. Effect of sodium bicarbonate on the development of gastric stasis in the rat model of myeloablative chemotherapy with cyclophosphamide. Extreme Medicine. 2023; (2): 91–7.
  2. Lallès J-P. Recent advances in intestinal alkaline phosphatase, inflammation, and nutrition. Nutrit Rev. 2019; 77 (10): 710–24.
  3. Sine JP. Acetylcholinesterase and butyrylcholinesterase in the gut mucosal cells of various mammal species: distribution along the intestine and molecular forms. Compar Biochem Physiol. C Comp Pharmacol Toxicol. 1988; 91 (2): 597–602.
  4. Dawson ME. A wealth of options. Choosing an LAL test method. Associates of Cape Cod, Inc., Woods Hole, Massachusetts. LAL Update. 1995; 13 (3): 1–6.
  5. Martynov VL, Semenov AG, Tulupov AA, Chesnokov AA, Kurilov VA, Kazarina NV. Urine indican and hydrogen breath test as methods of screening diagnosis of bacterial overgrowth syndrome in the small intestine. Med. Almanakh. 2017; 2 (47): 117–21. Russian.
  6. Balakhovskiy SD, Balakhovskiy IS. Methods of chemical blood analysis. 3-rd ed. Moscow.: Medgiz, 1953; 746 p. Russian.
  7. Zar JH. Biostatistical Analysis. 5th ed. Prentice-Hall/Pearson: Upper Saddle River, 2010; 944 p.
  8. Ivnitsky JuJu, Schäfer TV, Tyaptin AA, Rejniuk VL. Changes in the chemical composition of the blood and brain of rats under the conditions of modeling the myeloablation regimen of cyclophosphamide administration. Toxicologicheskiy vestnik. 2019; 156 (3): 13–8. Russian.
  9. Sender R, Fuchs S. Revised estimates for the number of human and bacteria cells in the body. PLoS Biol. 2016; 14 (8): e1002533.
  10. Bested AC, Logan AC, Selhub EM. Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part II – contemporary contextual research. Gut Pathog. 2013; 5 (1): 3.
  11. Heda R, Toro F, Tombazzi CR. Physiology, pepsin. In: StatPearls. StatPearls Publishing: 2024. Available from: https://www.ncbi. nlm.nih.gov/books/NBK537005/.
  12. Visnovsky P. The effect of cyclophosphamide and methotrexate on gastric emptying and secretion in rats. Bratisl Lek Listy. 1992; 93 (2): 90–2.
  13. Dahlgren D, Sjöblom M, Hellström P, Lennemäs H. Chemotherapeutics-induced intestinal mucositis: pathophysiology and potential treatment strategies. Front Pharmacol. 2021; 12 (Art. 681417): 1–12.
  14. Ott P, Vilstrup H. Cerebral effects of ammonia in liver disease: current hypotheses. Metab Brain Dis. 2014; 29 (4): 901–11.
  15. Khubutiya MSh, Kabanova SA, Goldfarb YuS, Matkevich VA, Bogopolskiy PM, Badalyan AV. Prognosis of the development of clinical toxicology in Russia. Zhurnal im. N.V. Sklifosovskogo «Neotlozhnaya meditsinskaya pomoshch». 2016; (3): 26–31. Russian.