Role of radiology techniques and hybrid PET-MRI technique in the diagnosis of pharmacoresistant epilepsy

Dolgushin MB, Rostovtseva TM, Duyunova AV, Nadelyaev RV, Beregov MM
About authors

Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency, Moscow, Russia

Correspondence should be addressed: Tatiana M. Rostovtseva
Ostovityanov, 1, bld. 10, 117513, Moscow, Russia; ur.liam@tavestvotsor

About paper

Funding: the study was performed as part of the research project “Developing Indications for the Use of Hybrid PET-MRI When Planning Surgery in Patients With Epilepsy”, code: 03.02.VY.

Author contribution: all authors contributed significantly to development of the concept, the study and manuscrit writing, they read and approved the final version of the article before publishing. The most significant contributions are distributed as follows: Dolgushin MB — study concept and plan; Rostovtseva TM, Duyunova AV, Nadelyaev RV Duyunova AV, Nadelyaev RV — data acquisition and analysis; Rostovtseva TM, Duyunova AV, Beregov MM — manuscrit writing.

Received: 2023-03-31 Accepted: 2023-05-14 Published online: 2023-06-01

The surgical treatment outcome in patients with pharmacoresistant epilepsy directly depends on the epileptic focus localization accuracy. Conventional diagnostic algorithms for patients with epilepsy involve starting with video EEG monitoring and magnetic resonance imaging. It is not possible to localize epileptogenic foci with the use of these techniques in a large segment of patients with pharmacoresistant epilepsy, or the test results are discordant. The review provides the analysis of literature data on the current possibilities of SPECT, PET and new hybrid PET-MRI technique when used for preoperative planning in patients with refractory epilepsy.

Keywords: epilepsy, SPECT, PET, MRI, PET-MRI