2023 / 03

Следующая статья
DOI: 10.47183/mes.2023.030

ОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕ

Вычислительный фантом для дозиметрии красного костного мозга годовалого ребенка от инкорпорированных бета-излучателей

П. А. Шарагин1, Е. А. Шишкина1,2, Е. И. Толстых1
Информация об авторах

1 Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства, Челябинск, Россия

2 Челябинский государственный университет, Челябинск, Россия

Для корреспонденции: Павел Алексеевич Шарагин
ул. Воровского, д. 68-а, г. Челябинск, 454141, Россия; ur.mrcru@nigarahs

Информация о статье

Финансирование: работа выполнена в рамках реализации федеральной целевой программы «Федеральная целевая программа «Обеспечение ядерной и радиационной безопасности на 2016–2020 годы и на период до 2035 года» и при финансовой поддержке Федерального медико-биологического агентства России.

Вклад авторов: П. А. Шарагин — получение, анализ и интерпретацию данных, написание и редактирование статьи; Е. И. Толстых — разработка методики исследования, редактирование статьи; Е. А. Шишкина — разработка концепции, редактирование статьи.

Статья получена: 14.06.2023 Статья принята к печати: 23.08.2023 Опубликовано online: 26.09.2023
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  1. Degteva MO, Shagina NB, Vorobiova MI, Shishkina EA, Tolstykh EI, Akleyev AV. Contemporary Understanding of Radioactive Contamination of the Techa River in 1949-1956. Radiats Biol Radioecol. 2016; 56 (5): 523–34.PMID: 30703313. Russian.
  2. Krestinina LY, Epifanova S, Silkin S, Mikryukova L, Degteva M, Shagina N, et al. Chronic low-dose exposure in the Techa River Cohort: risk of mortality from circulatory diseases. Radiat Environ Biophys. 2013; 52 (1): 47–57. DOI: 10.1007/s00411-012-0438-5. Epub 2012 Nov 4.
  3. Аклеев А. В. Хронический лучевой синдром у жителей прибрежных сел реки Теча. Челябинск: Книга, 2012; 464 с.
  4. Preston DL, Sokolnikov ME, Krestinina LY, Stram DO. Estimates of radiation effects on cancer risks in the mayak worker, Techa river and atomic bomb survivor studies. Radiat Prot Dosimetry. 2017; 173 (1–3): 26–31. DOI: 10.1093/rpd/ncw316.
  5. Degteva MO, Napier BA, Tolstykh EI, et al. Enhancements in the Techa river dosimetry system: TRDS-2016D Code for reconstruction of deterministic estimates of dose from environmental exposures. Health Phys. 2019; 117 (4): 378–87. DOI: 10.1097/HP.0000000000001067.
  6. Spiers FW, Beddoe AH, Whitwell JR. Mean skeletal dose factors for beta-particle emitters in human bone. Part I: volume-seeking radionuclides. The British journal of radiology. 1978; 51 (608): 622–7.
  7. Силкин С. С., Крестинина Л. Ю., Старцев Н. В, Аклеев А. В. Уральская когорта аварийно-облученного населения. Медицина экстремальных ситуаций. 2019; 21 (3): 393–402.
  8. O'Reilly SE, DeWeese LS, Maynard MR, Rajon DA, Wayson MB, Marshall EL, et al. An 13 image-based skeletal dosimetry model for the ICRP reference adult female-internal electron 14 sources. Phys Med Biol. 2016 Dec 21; 61 (24): 8794–824. Epub 2016 Nov 29.
  9. Xu XG, Chao TC, Bozkurt A. VIP-Man: an image-based wholebody adult male model constructed from color photographs of the Visible Human Project for multi-particle Monte Carlo calculations. Health Phys. 2000; 78 (5): 476–86. DOI: 10.1097/00004032200005000-00003. PMID: 10772019.
  10. Shah AP, Bolch WE, Rajon DA, Patton PW, Jokisch DW. A pairedimage radiation transport model for skeletal dosimetry. J Nucl Med. 2005; 46 (2): 344–53. PMID: 15695796.
  11. Pafundi D. Image-based skeletal tissues and electron dosimetry models for the ICRP reference pediatric age series. A dissertation presented to the graduate schools of the University of Florida in partial fulfillment of the requirements for the degree of doctor of the philosophy. University of Florida. 2009.
  12. Hough M, Johnson P, Rajon D, Jokisch D, Lee C, Bolch W. An image-based skeletal dosimetry model for the ICRP reference adult male–internal electron sources. Phys Med Biol. 2011; 56 (8): 2309–46. DOI: 10.1088/0031-9155/56/8/001.
  13. Degteva MO, Tolstykh EI, Shishkina EA, Sharagin PA, Zalyapin VI, Volchkova AYu, et al. PLoS One. 2021; 16 (10): e0257605. DOI: 10.1371/journal.pone.0257605. PMID: 34648511; PMCID: PMC8516275.PlosOne.
  14. Дёгтева М. О., Шишкина Е. А., Толстых Е. И., Заляпин В. И., Шарагин П. А., Смит М. А., и др. Методологический подход к разработке дозиметрических моделей скелета человека для бета-излучающих радионуклидов. Радиационная гигиена. 2019; 12 (2). DOI: 10.21514/1998-426X-2019-12-2-66-75.
  15. Volchkova AYu, Sharagin PA, Shishkina EA. Internal bone marrow dosimetry: the effect of the exposure due to 90Sr incorporated in the adjacent bone segments. Bulletin of the South Ural State University. Ser. Mathematical Modelling, Programming & Computer Software. 2022; 15 (4): 44–58. DOI: 10.14529/mmp220404.
  16. Шарагин П. А., Шишкина Е. А., Толстых Е. И. Вычислительный фантом для дозиметрии красного костного мозга новорожденного ребенка от инкорпорированных бетаизлучателей. Медицина экстремальных ситуаций. 2022; (4): 74–82. DOI: 10.47183/mes.2022.045.
  17. Cristy M. Active bone marrow distribution as a function of age in humans. Phys Med Biol. 1981; 26 (3): 389–400.
  18. Sharagin PA, Shishkina EA, Tolstykh EI, Volchkova AYu, Smith MA, Degteva MO. Segmentation of hematopoietic sites of human skeleton for calculations of dose to active marrow exposed to bone-seeking radionuclides. RAD Conference Proceedings. 2018; (3): 154–8. DOI: 10.21175/RadProc.2018.33.
  19. Шарагин П. А., Толстых Е. И., Шишкина Е. А., Дегтева М. О. Дозиметрическое моделирование кости для остеотропных бета-излучающих радионуклидов: размерные параметры и сегментация. В сборнике: Материалы международной научной конференции “Современные проблемы радиобиологии”. Беларусь, Гомель, 23-24 сентября 2021; с. 200–204.
  20. Толстых Е. И., Шарагин П. А., Шишкина Е. А., Дегтева М. О. Формирование доз облучения красного костного мозга человека от 89,90Sr, оценка параметров трабекулярной кости для дозиметрического моделирования. В сборнике: Материалы международной научной конференции “Современные проблемы радиобиологии”. Беларусь, Гомель, 23–24 сентября 2021; с. 176–179.
  21. Толстых Е. И., Шарагин П. А., Шишкина Е. А., Волчкова А. Ю. Дегтева М. О. Анатомо-морфологический базис для дозиметрического моделирования трабекулярной кости человека с использованием стохастического параметрического подхода. Клинический вестник ГНЦ ФМБЦ им. А. И. Бурназяна. 2022; 3: 25–40.
  22. Valentin J. Basic anatomical and physiological data for use in radiological protection: reference values. Annals of the ICRP. Annals of the ICRP. 2002; 32 (3–4): 1–277.
  23. Shishkina EA, Timofeev YS, Volchkova AY, Sharagin PA, Zalyapin VI, Degteva MO, et al. Trabecula: a random generator of computational phantoms for bone marrow dosimetry. Health Phys. 2020; 118 (1): 53–59. DOI: 10.1097/HP.0000000000001127.
  24. Zalyapin VI, Timofeev YuS, Shishkina EA. A parametric stochastic model of bone geometry. Bulletin of Southern Urals State University, Issue «Mathematical Modelling. Programming & Computer Software» (SUSU MMCS) 2018; 11 (2): 44–57. DOI: 10.14529/mmp180204.
  25. Robinson RA. Chemical analysis and electron microscopy of bone. In: Rodahl K, Nicholson JT, Brown EM editors. Bone as a tissue. New York: McGraw-Hill, 1960; p. 186–250.
  26. Vogler JB 3rd, Murphy WA. Bone marrow imaging. Radiology. 1988; 168 (3): 679–93.
  27. Vande Berg BC, Malghem J, Lecouvet FE, Maldague B. Magnetic resonance imaging of the normal bone marrow. Skeletal Radiology. 1998; 27: 471–83.
  28. Vande Berg BC, Malghem J, Lecouvet FE, Maldague B. Magnetic resonance imaging of normal bone marrow. Eur Radiol. 1998; 8 (8): 1327–34.
  29. Taccone A, Oddone M, Dell'Acqua AD, Occhi M, Ciccone MA. MRI "road–map" of normal age-related bone marrow. II. Thorax, pelvis and extremities. Pediatr Radiol. 1995; 25 (8): 596–606; PubMed PMID: 8570312.
  30. Taccone A, Oddone M, Occhi M, Dell'Acqua AD, Ciccone MA. MRI "road–map" of normal age-related bone marrow. I. Cranial bone and spine. Pediatr Radiol. 1995; 25 (8): 588–95; PubMed PMID: 8570311.
  31. Cunningham C, Scheuer L, Black S. Developmental juvenile osteology. Elsevier Academic Press, 2016.
  32. Ryan TM, Krovitz GE. Trabecular bone ontogeny in the human proximal femur. J Hum Evol. 2006; 51 (6): 591–602.
  33. Milovanovic P, Djonic D, Hahn M, Amling M, Busse B, Djuric M. Region-dependent patterns of trabecular bone growth in the human proximal femur: A study of 3D bone microarchitecture from early postnatal to late childhood period. Am J Phys Anthropol. 2017; 164 (2): 281–91. DOI: 10.1002/ajpa.23268. Epub 2017 Jun 20.
  34. Saers JP, Cazorla-Bak Y, Shaw CN, Stock JT, Ryan TM. Trabecular bone structural variation throughout the human lower limb. J Hum Evol. 2016; 97: 97–108. DOI: 10.1016/j.jhevol.2016.05.012.
  35. Ryan TM, Raichlen DA, Gosman JH. Structural and mechanical changes in trabecular bone during early development in the human femur and humerus. In: Building bones: bone formation and development in anthropology. Cambridge University Press, 2017; p. 281–302. Available from: https://doi. org/10.1017/9781316388907.013.
  36. Byers S, Moore AJ, Byard RW, Fazzalari NL. Quantitative histomorphometric analysis of the human growth plate from birth to adolescence. Bone. 2000; 27 (4): 495–501.
  37. Gosman JH, Ketcham RA. Patterns in ontogeny of human trabecular bone from SunWatch Village in the Prehistoric Ohio Valley: general features of microarchitectural change. Am J Phys Anthropol. 2009; 138 (3): 318–32. DOI: 10.1002/ajpa.20931. PubMed PMID: 18785633.
  38. Volpato V. Bone endostructure morphogenesis of the human ilium. Comptes rendus Palévol. 2008; 7: 463–71. DOI: 10.1016/j. crpv.2008.06.001.
  39. Glorieux FH, Travers R, Taylor A, Bowen JR, Rauch F, Norman M, et al. Normative data for iliac bone histomorphometry in growing children. Bone. 2000; 26 (2): 103–9.
  40. Rodriguez-Florez N, Ibrahim A, Hutchinson JC, Borghi A, James G, Arthurs OJ, et al. Cranial bone structure in children with sagittal craniosynostosis: relationship with surgical outcomes. J Plast Reconstr Aesthet Surg. 2017; 70 (11): 1589–97. DOI: 10.1016/j. bjps.2017.06.017.
  41. Hough M, Johnson P, Rajon D, Jokisch D, Lee C, Bolch W. An image-based skeletal dosimetry model for the ICRP reference adult male—internal electron sources. Phys Med Biol. 2011; 56 (8): 2309–46.
  42. Acquaah F, Robson Brown KA, Ahmed F, Jeffery N, Abel RL. Early trabecular development in human vertebrae: overproduction, constructive regression, and refinement. Front Endocrinol (Lausanne). 2015; 6: 67. DOI: 10.3389/fendo.2015.00067. eCollection 2015.
  43. Florence JL. Linear and cortical bone dimensions as indicators of health status in subadults from the Milwaukee County Poor Farm Cemetery. M.A., University of Colorado at Denver, 2007.
  44. Miles AEW. Growth cuves of immature bones from a scottish island population of sixteenth to mid-nineteenth century: limb-bone diaphyses and some bones of the hand and foot. International Journal of Osteoarcheology. 1994; 4: 121–36.
  45. Maresh MM. Measurements from roentgenograms. In: McCammon RW, editor. Human Growth and Development. Springfield, IL: Charles C. Thomas, 1970; p. 157–200.
  46. Dhavale N, Halcrow SE, Buckley HR, Tayles N, Domett KM, Gray AR. Linear and appositional growth in infants and children from the prehistoric settlement of Ban Non Wat, Northeast Thailand: evaluating biological responses to agricultural intensification in Southeast Asia. Journal of Archaeological Science: Reports. 2017; 11: 435–46.
  47. Svadovsky VS. Age-related bone remodeling. Moscow, 1961.
  48. Danforth ME, Wrobel GD, Armstrong CW, Swanson D. Juvenile age estimation using diaphyseal long bone lengths among ancient Maya populations. Latin American Antiquity. 2017; 20 (1): 3–13.
  49. Beresheim AC, Pfeiffer S, Grynpas M. Ontogenetic changes to bone microstructure in an archaeologically derived sample of human ribs. J Anat. 2019. DOI: 10.1111/joa.13116
  50. Pfeiffer S. Cortical Bone Histology in Juveniles. Available from: https://www.researchgate.net/publication/303179375_Cortical_ bone_histology_in_Juveniles
  51. Hresko AM, Hinchcliff EM, Deckey DG, Hresko MT. Developmental sacral morphology: MR study from infancy to skeletal maturity. Eur Spine J. 2020. Available from: https://doi.org/10.1007/s00586020-06350-6.
  52. Kузнецов Л. Е. Переломы таза у детей: морфология, биомеханика, диагностика. М.: Фолиум, 1994.
  53. Mavrych V, Bolgova O, Ganguly P, Kashchenko S. Age-related сhanges of lumbar vertebral body morphometry. Austin J Anat. 2014; 1 (3): 7.
  54. Dimeglio A, Bonnel F, Canavese F. The Growing Spine. In: Jean Marc Vital, Derek Thomas Cawley, editors. Spinal Anatomy. Modern Concepts. Springer, 2020; p. 25–52.
  55. Андроневский А. Анатомия ребенка. Бухарест: Меридиан, 1970.
  56. Bernert Zs, Évinger S, Hajdu T. New data on the biological age estimation of children using bone measurements based on historical populations from the Carpathian Basin. Annales Historico-Naturales Musei Nationalis Hungarici. 2007; 99: 199– 206.
  57. Gindhart PS. Growth standards for the tibia and radius in children aged one month through eighteen years. Am J Phys Anthrop. 1973; 39: 41–48.
  58. Lopez-Costas O, Rissech C, Trancho G, Turbón D. Postnatal ontogenesis of the tibia. Implications for age and sex estimation. Forensic Sci Int. 2012; 214 (1–3): 207.e1–11. DOI: 10.1016/j. forsciint.2011.07.038. Epub 2011 Aug 20. PubMed PMID: 21862250.
  59. Blake KAS. An investigation of sex determination from the subadult pelvis: a morphometric analysis. Doctoral Dissertation, University of Pittsburgh. 2011.
  60. Cunningham CA, Black SM. Iliac cortical thickness in the neonate - the gradient effect. J Anat. 2009; 215 (3): 364–70. DOI: 10.1111/j.1469-7580.2009.01112.x.
  61. Cunningham CA, Black SM. Anticipating bipedalism: trabecular organization in the newborn ilium. J Anat. 2009; 214 (6): 817–29. DOI: 10.1111/j.1469-7580.2009.01073.x
  62. Corron L, Marchal F, Condemi S, Chaumoître K, Adalian P. A New Approach of Juvenile Age Estimation using Measurements of the Ilium and Multivariate Adaptive Regression Splines (MARS) Models for Better Age Prediction. Forensic Sci. 2017; 62 (1): 18–29. DOI: 10.1111/1556-4029.13224.
  63. Parfitt AM, Travers R, Rauch F, Glorieux FH. Structural and cellular changes during bone growth in healthy children. Bone. 2000; 27 (4): 487–94. PMID: 11033443.
  64. Schnitzler CM, Mesquita JM, Pettifor JM. Cortical bone development in black and white South African children: iliac crest histomorphometry. Bone. 2009; 44 (4): 603–11. DOI: 10.1016/j. bone.2008.12.009.
  65. De Boer HH, Van der Merwe AE, Soerdjbalie-Maikoe VV. Human cranial vault thickness in a contemporary sample of 1097 autopsy cases: relation to body weight, stature, age, sex and ancestry. Int J Legal Med. 2016; 130 (5): 1371–7. DOI: 10.1007/s00414-0161324-5.
  66. Margulies S, Coats B. Experimental injury biomechanics of the pediatric head and brain. Chapter 4. In: Crandall JR, Myers BS, Meaney DF, Schmidtke SZ, editors. Pediatric Injury Biomechanics Springer Science + Business Media New York. 2013; p. 157–190.
  67. Li Z, Park BK, Liu W, Zhang J, Reed MP, Rupp JD, et al. A statistical skull geometry model for children 0–3 years old. PLoS One. 2015 May 18; 10 (5): e0127322. DOI: 10.1371/journal.pone.0127322. eCollection 2015.
  68. Rodriguez-Florez N, Ibrahim A, Hutchinson JC, Borghi A, James G, Arthurs OJ, et al. Cranial bone structure in children with sagittal craniosynostosis: Relationship with surgical outcomes. J Plast Reconstr Aesthet Surg. 2017; 70 (11): 1589–97. DOI: 10.1016/j. bjps.2017.06.017.
  69. McGraw MA, Mehlman CT, Lindsell CJ, Kirby CL. Postnatal growth of the clavicle: birth to eighteen years of age. Journal of Pediatric Orthopedics. 2009; 29: 937.
  70. Bleuze MM, Wheeler SM, Williams LJ, Dupras TL. Growth of the pectoral girdle in a sample of juveniles from the kellis 2 cemetery, Dakhleh Oasis, Egypt. Am J Hum Biol. 2016; 28 (5): 636–45.
  71. Black SM, Scheuer JL. Age changes in the clavicle: from the early neonatal period to skeletal maturity. International Journal of Osteoarchaeology. 1996; 6: 425–34.
  72. Bernat A, Huysmans T, Van Glabbeek F, Sijbers J, Gielen J, Van Tongel A. The anatomy of the clavicle: a three-dimensional cadaveric study. Clin Anat. 2014; 27 (5): 712–23.
  73. Vallois HV. L’omoplate humaine. Bulletin de la Sociétié d’Anthropolgie de Paris. 1946; 7: 16–99.
  74. Saunders S, Hoppa R, Southern R. Diaphyseal growth in a nineteenth-century skeletal sample of subadults from St Thomas’ Church, Belleville, Ontario. International Journal of Osteoarchaeology. 1993; 3: 265–81.
  75. Rissech C, Black S. Scapular development from neonatal period to skeletal maturity. A preliminary study. Int J Osteoarchaeol. 2007; 17: 451–64.
  76. Cardoso HFV, Spake L, Humphrey LT. Age estimation of immature human skeletal remains from the dimensions of the girdle bones in the postnatal period. Am J Phys Anthropol. 2017; 163 (4): 772–83. DOI: 10.1002/ajpa.23248. Epub 2017 May 24. PubMed PMID: 28542741.
  77. Badr El Dine F, Hassan H. Ontogenetic study of the scapula among some Egyptians: Forensic implications in age and sex estimation using Multidetector Computed Tomography, Egyptian Journal of Forensic Sciences. 2015; 6 (2): 56–77.
  78. Kneissel M, Roschger P, Steiner W, Schamall D, Kalchhauser G, Boyde A, et al. Cancellous Bone Structure in the Growing and Aging Lumbar Spine in a Historic Nubian Population. Calcif Tissue Int. 1997; 61: 95–100.
  79. Johnson KT, Al-Holou WN, Anderson RC, Wilson TJ, Karnati T, Ibrahim M, et al. Morphometric analysis of the developing pediatric cervical spine. J Neurosurg Pediatr. 2016; 18 (3): 377–89. DOI: 10.3171/2016.3. PEDS1612. Epub 2016 May 27. PubMed PMID: 27231821.
  80. Comeau A. Age-related changes in geometric characteristics of the pediatric thoracic cage and comparison of thorax shape with a pediatric CPR Manikin. PhD thesis. 2010.